Endocrine Abstracts

Anti-Müllerian hormone (AMH), known for its role in fetal development and female reproduction, is also present in adult and elderly men in considerable amounts. In recent years, controversial findings regarding relations to age, other hormones, and BMI (possibly based on a dilutional effect due to higher blood volume) have been discussed. To date, little is known of its clinical relevance in this population. We aimed to further investigate AMH levels in an aging male popu...

Background: A negative relationship between body mass index (BMI) and serum Anti-Müllerian hormone (AMH) levels has been previously reported. Whether this is because of an adverse effect of adiposity on AMH production or the hormone’s dilution in a higher blood volume that accompanies larger body size (‘hemodilution’) is not yet clear. Blood volume can be estimated by body weight, body surface area (BSA) or lean mass (LM). Of note, adipose tissue is poorly ...

Sarcopenia is characterized by progressive loss of both mass and function of skeletal muscle when ageing. It poses a serious issue for healthcare systems, as it is associated with increased risk of falls, osteoporosis, and mortality. To date, no ideal serum biomarkers for the diagnosis of this complex condition have been identified. Matrix-GLA-protein (MGP), primarily known as a vitamin K dependent calcification inhibitor, is present and active in bone, muscle, and adipose tis...